Obsession with Nicotine as Sole Component of Smoking Addiction

This month's issue of the journal Nicotine and Tobacco Research is devoted to articles on the study of nicotine receptors in mice and rats.

The articles in the issue include:

    Nicotinic ACh Receptors in the Hippocampus: Role in Excitability and Plasticity
    Preclinical Evidence That Activation of Mesolimbic Alpha 6 Subunit Containing Nicotinic Acetylcholine Receptors Supports Nicotine Addiction Phenotype
    Nicotinic Regulation of Energy Homeostasis
    From Men to Mice: CHRNA5/CHRNA3, Smoking Behavior and Disease Impact of Tobacco Regulation on Animal Research: New Perspectives and Opportunities
    Pharmacological Differences Between Rat Frontal Cortex and Hippocampus in the Nicotinic Modulation of Noradrenaline Release Implicate Distinct Receptor Subtypes
    Mice Lacking the β4 Subunit of the Nicotinic Acetylcholine Receptor Show Memory Deficits, Altered Anxiety- and Depression-Like Behavior, and Diminished Nicotine-Induced Analgesia
    Bupropion and its Main Metabolite Reverse Nicotine Chronic Tolerance in the Mouse

The issue also includes a summary review article of the significance of this research for the development of new smoking cessation drugs, which features as its example of the implications of this line of research the development of the nicotine vaccine.